Glucose Control and Complications: New Trials Modify the Paradigm

Presented By:		William C. Duckworth, MD Professor of Clinical Medicine The University of Arizona, College of Medicine--Phoenix Director, Diabetes Research VA Medical Center Phoenix, Arizona Research Professor, Biodesign Research Arizona State University Professor of Clinical Medicine Midwestern University College of Health Sciences Glendale, Arizona Adjunct Clinical Assistant Professor in Endocrinology Kirksville College of Osteopathic Medicine Kirksville, Missouri

Program Description:	This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, followed by an online post-test. Estimated time to complete this activity, including review of materials, is 30 minutes.
General Information:	Requirements for Successful Completion: This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, which is followed by an online post-test. There is no fee to participate in this CME activity or to receive CME credit. Certificates are awarded upon successful completion (80% proficiency) of the post-test. In order to receive credit, participants must view the presentaion in its entirety. Media: Internet Release Date:    July 24, 2009 Expiration Date:  July 23, 2011
Target Audience:	Clinical Cardiologists, Endocrinologists, Certified Diabetes Educators, Family Practice/General Physicians, Internal Medicine Physicians, Medical Directors, Nephrologists, Nurse Practitioners, Primary Care Physicians, Physician Assistants, Specialty Physicians, Nurses, Pharmacists
Program Overview:	Epidemiological data support the idea that hyperglycemia has deleterious effects on micro- and macrovascular outcomes. However, no clear prospective data show cardiovascular risk reduction as a result of tight glycemic control. The Veterans Affairs Diabetes Trial (VADT), Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation(ADVANCE), and United Kingdom Prospective Diabetes Study (UKPDS) examined the effects of glucose control on macrovascular cardiovascular events. However, there is a paucity of data supporting cardiovascular risk reduction as a result of tight glycemic control. This CME online activity compares and contrasts the results of these 4 landmark trials and puts the data in perspective to each other and to the broad clinical care of patients with glycemic abnormalities.
Learning Objectives:	a. Name a principal endpoint of the VADT, ACCORD, ADVANCE, and UKPDS trials b. Indicate how glycemic control can decrease microvascular disease c. Define the potential benefit of glucose control in macrovascular events in early type 2 diabetes
Faculty Disclosure:	The University of Florida College of Medicine has a conflict of interest policy that requires course faculty to disclose any real or apparent commercial financial affiliations related to the content of their presentations/materials. It is not assumed that these financial interests or affiliations will have an adverse impact on faculty presentations; they simply are noted here to fully inform participants. Dr Duckworth has indicated that he has a financial arrangement or affiliation with Hoffmann-La Roche, Novo Nordisk, Caremark, L.L.C. The types of affiliations/financial interests are grant/research support and consultant agreements.
Continuing Medical Education Credit:
	Accreditation
	The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
	Credit
	The University of Florida College of Medicine designates this educational activity for a maximum of .50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
	This continuing education activity was planned in accordance with the ACCME essentials and reviewed by Carl J. Pepine, MD, Program Chair.
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Commercial Support:	This CME activity is supported by an educational grant from sanofi-aventis U.S.
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CME Contact:	For any question regarding this Internet CME activity, please contact the Office of Continuing Medical Education at 352-265-8081.
	The University of Florida College of Medicine has received permission to use this copyrighted material within a CME activity on the internet.

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