Physiologic Basis of Hyperglycemia in Macro- and Microvascular Disease

Presented By:		Richard W. Nesto, MD, FACC, FAHA Associate Professor of Medicine Harvard Medical School Boston, Massachusetts Chairman, Department of Cardiovascular Medicine Lahey Clinic Medical Center Burlington, Massachusetts

Program Description:	This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, followed by an online post-test. Estimated time to complete this activity, including review of materials, is 30 minutes.
General Information:	Requirements for Successful Completion: This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, which is followed by an online post-test. There is no fee to participate in this CME activity or to receive CME credit. Certificates are awarded upon successful completion (80% proficiency) of the post-test. In order to receive credit, participants must view the presentaion in its entirety. Media: Internet Release Date:    June 2, 2009 Expiration Date:  June 1, 2011
Target Audience:	Certified Diabetes Educators, Primary Care Physicians, Clinical Cardiologists, Endocrinologists, Family Practice, General Physicians, Internal Medicine Physicians, Medical Directors, Nephrologists, Nurse Practitioners, Physician Assistants, Pharmacists
Program Overview:	The consequences of macro- and microvascular complications attributable to type 2 diabetes (T2DM) are considerable. Diabetes-associated macro- and microvascular effects have a different time of onset and, as related to glucose threshold, they are prognostically linked as coexistent partners in the progression of diabetes-related comorbidities. These effects, however, are not necessarily caused by shared mechanisms of disease. Furthermore, successful treatment approaches to reducing macro- and microvascular disease do not seem to be aligned with one another. Since hyperglycemia appears to be a modulator in the progression of macro- and microvascular disease, what are the implications for the cardiologist? This CME activity will examine the evidence and underlying pathophysiology of hyperglycemia in the context of both cardiovascular disease and microvascular disease, including diabetic retinopathy, heart failure risk, autonomic dysfunction, peripheral artery disease, and nephropathy.
Learning Objectives:	a) Demonstrate a link between hyperglycemia and free fatty acids in diabetes-related complications b) Define whether a glucose threshold exists, underlying macro- or microvascular diseases in T2DM c) Indicate new data supporting effective treatment options for coronary artery disease and T2DM
Faculty Disclosure:	The University of Florida College of Medicine has a conflict of interest policy that requires course faculty to disclose any real or apparent commercial financial affiliations related to the content of their presentations/materials. It is not assumed that these financial interests or affiliations will have an adverse impact on faculty presentations; they simply are noted here to fully inform participants. Dr. Richard W. Nesto has indicated that he has a financial arrangement or affiliation with GlaxoSmithKline, sanofi-aventis U.S., and Merck & Co., Inc. The type of affiliation/financial interest is honoraria.
Continuing Medical Education Credit:
	Accreditation
	The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
	Credit
	The University of Florida College of Medicine designates this educational activity for a maximum of .50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
	This continuing education activity was planned in accordance with the ACCME essentials and reviewed by Carl J. Pepine, MD, Program Chair.
	Click here for disclosure and disclaimer information
Commercial Support:	This CME activity is supported by an educational grant from sanofi-aventis U.S.
System Requirements:	In order to view the presentation, your computer must have a media player such as Windows Media Player, Quicktime, or RealOne.
CME Contact:	For any question regarding this Internet CME activity, please contact the Office of Continuing Medical Education at 352-265-8081.
	The University of Florida College of Medicine has received permission to use this copyrighted material within a CME activity on the internet.

Take this presentation with you:
Download this Online Lecture as an MP3 and load it onto your iPod or other portable audio player.
MP3 Audio File
(Right-click and select "Save Target As..." to download)