Integrating Innovative Strategies in Cardiometabolic Risk Reduction

Presented By:		Caroline M. Apovian, MD, FACP, FACN Associate Professor of Medicine and Pediatrics Boston University School of Medicine Director, Center for Nutrition and Weight Management Boston Medical Center Boston, Massachusetts

Program Description:	This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, followed by an online post-test. Estimated time to complete this activity, including review of materials, is 30 minutes.
General Information:	Requirements for Successful Completion: This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, which is followed by an online post-test. There is no fee to participate in this CME activity or to receive CME credit. Certificates are awarded upon successful completion (80% proficiency) of the post-test. In order to receive credit, participants must view the presentaion in its entirety. Media: Internet Release Date:    December 22, 2008 Expiration Date:  December 21, 2010
Target Audience:	Clinical Cardiologists, Endocrinologists, Internal Medicine Physicians, Lipidologists
Program Overview:	Obesity, dysglycemia, dyslipidemia, and hypertension frequently cluster and are major risk factors for both diabetes and cardiovascular (CV) disease. The impact of these risk factors is amplified by lifestyle (physical inactivity, smoking, and diet) as well as by genetics, gender, and age. Chronic energy imbalance caused by an excess of calories consumed vs expended leads to increased storage of triglycerides within adipocytes, which in turn causes both increased adipocyte size and adipocyte number. Manifestations of this process include increased levels of proatherogenic and pro-inflammatory cytokines, free fatty acids, and inflammatory mediators. Diet and increased physical activity are first-line therapies for lowering cardiometabolic risk factors. Being physically active attenuates the CV disease risk associated with excess adiposity, but it does not completely abolish it, emphasizing the importance of being both lean and physically active. However, regular follow-up and support to encourage adherence to the diet selected and to physical activity recommendations are essential. This CME program will translate the latest research into practical, clinical approaches for reducing cardiometabolic risk. In particular, this program will review current and emerging pharmacologic options for weight loss and recent data demonstrating that surgical weight loss is associated with improved survival and a reduction in CV outcomes.
Learning Objectives:	• Recognize central adiposity as a cardiometabolic risk factor to identify patients at high risk of cardiovascular disease • Review outcomes data on weight loss as a cardioprotective strategy in order to incorporate evidence-based medicine "pearls" in clinical practice
Faculty Disclosure:	The University of Florida College of Medicine has a conflict of interest policy that requires course faculty to disclose any real or apparent commercial financial affiliations related to the content of their presentations/materials. It is not assumed that these financial interests or affiliations will have an adverse impact on faculty presentations; they simply are noted here to fully inform participants. Caroline M. Apovian, MD, has indicated that she has a financial arrangement or affiliation with sanofi-aventis, Gate Pharmaceuticals, Merck & Co Inc, GlaxoSmithKline, Pfizer Inc, and Amylin Pharmaceuticals Inc. The types of affiliations/financial interests are grant/research support, consultant agreements, and honoraria.
Continuing Medical Education Credit:
	Accreditation
	The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
	Credit
	The University of Florida College of Medicine designates this educational activity for a maximum of .50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
	This continuing education activity was planned in accordance with the ACCME essentials and reviewed by Carl J. Pepine, MD, Program Chair.
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Commercial Support:	This CME activity is supported by an educational grant from sanofi-aventis.
System Requirements:	In order to view the presentation, your computer must have a media player such as Windows Media Player, Quicktime, or RealOne.
CME Contact:	For any question regarding this Internet CME activity, please contact the Office of Continuing Medical Education at 352-265-8081.
	The University of Florida College of Medicine has received permission to use this copyrighted material within a CME activity on the internet.

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