Anti-inflammatory and Anti-atherogenic Effects of Insulin

Presented By:		Paresh Dandona, MBBS, DPhil, FRCP, FACP, FACC, FACE Distinguished Professor of Medicine Chief, Division of Endocrinology, Diabetes, and Metabolism State University of New York at Buffalo Director, Diabetes-Endocrinology Center of Western New York Buffalo, New York

Program Description:	This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, followed by an online post-test. Estimated time to complete this activity, including review of materials, is 1 hour.
General Information:	Requirements for Successful Completion: This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, which is followed by an online post-test. There is no fee to participate in this CME activity or to receive CME credit. Certificates are awarded upon successful completion (80% proficiency) of the post-test. In order to receive credit, participants must view the presentaion in its entirety. Media: Internet Release Date:    September 20, 2008 Expiration Date:  September 20, 2010
Target Audience:	Clinical Cardiologists, Endocrinologists, Internal Medicine Physicians, Lipidologists
Program Overview:	Hyperglycemia continues to be a major contributor to the rate of cardiovascular mortality in acute myocardial infarction (AMI). Maintaining euglycemia with insulin is a viable option that can minimize glycemic excursions, inflammation, and major adverse coronary events (ie, fatal and nonfatal myocardial infarction and stroke). New data on glycemic levels, inflammation, and the role of insulin have changed our understanding of hyperglycemia in acute coronary syndromes (ACS). From animal model studies to clinical trials in man, physicians need to understand the perilous consequences of hyperglycemia and the various treatments used to restore euglycemia. This CME activity is designed to educate physicians about the complex cellular interactions underlying hyperglycemia and the potential treatment options available to reverse the negative inflammatory effects by utilizing low-dose insulin regimens.
Learning Objectives:	Understand the complex physiological interactions that occur in the presence of hyperglycemia and the multiple causes of inflammation at a cellular level Recognize the mechanisms involved in inflammation and adverse coronary events to apply appropriate glucose-lowering therapies and maintain euglycemia Apply results from key clinical trials to high-risk patients with hyperglycemia and acute coronary syndromes
Faculty Disclosure:	The University of Florida College of Medicine has a conflict of interest policy that requires course faculty to disclose any real or apparent commercial financial affiliations related to the content of their presentations/materials. It is not assumed that these financial interests or affiliations will have an adverse impact on faculty presentations; they simply are noted here to fully inform participants. Dr Dandona has indicated that he has a financial arrangement or affiliation with GlaxoSmithKline, Novo Nordisk, Bristol-Myers Squibb,Takeda Pharmaceuticals, Allergan, sanofi-aventis, Conjuchem, Dannipon Pharmaceuticals, Procter & Gamble Pharma, Mitsubishi Tanabe Pharma, Quigley Pharma Inc, Solvay Pharmaceuticals, Transition Therapeutics, ToleRx, National Institutes of Health, Centers for Disease Control, Novartis Pharmaceuticals, Abbott Laboratories, Sankyo Pharmaceuticals North America, Oishei Foundation, Citrus Industry of Florida, William G. McGowan Charitable Fund, Millard Fillmore Foundation. The types of affiliations/financial interests are grant/research support and honoraria.
Continuing Medical Education Credit:
	Accreditation
	The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
	Credit
	The University of Florida College of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 CreditTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
	This continuing education activity was planned in accordance with the ACCME essentials and reviewed by Carl J. Pepine, MD, Program Chair.
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Commercial Support:	This CME activity is supported by an educational grant from sanofi-aventis.
System Requirements:	In order to view the presentation, your computer must have a media player such as Windows Media Player, Quicktime, or RealOne.
CME Contact:	For any question regarding this Internet CME activity, please contact the Office of Continuing Medical Education at 352-265-8081.
	The University of Florida College of Medicine has received permission to use this copyrighted material within a CME activity on the internet.

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