Mechanisms of RAAS Receptors in Cardioprotection

Presented By:		Arshed A. Quyyumi, MD, FACC, FRCP Professor of Medicine, Cardiology Emory University School of Medicine Atlanta, Georgia

Program Description:	This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format. Estimated time to complete this activity, including review of materials, is 1.5 hours.
General Information:	Requirements for Successful Completion: This CME activity consists of an educational component (ie, slides, audio lecture, newsletter) in an electronic format, which is followed by an online post-test. There is no fee to participate in this CME activity or to receive CME credit. Certificates are awarded upon successful completion (80% proficiency) of the post-test. In order to receive credit, participants must view the presentaion in its entirety. Media: Internet Release Date:    April 12, 2008 Expiration Date:  April 12, 2010
Target Audience:	Cardiologists, endocrinologists, and internists with an interest in CV disease.
Program Overview:	The renin-angiotensin-aldosterone system (RAAS) plays a major role in the pathophysiology of hypertension; modulation of the RAAS is a well-established approach to blood pressure reduction. Use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 (AT1) receptor blockers (ARBs) are at the front line in treating patients with hypertension and glucose abnormalities. Since the RAAS targets multiple pathways in the progression of atherosclerosis, greater understanding of RAAS cardiometabolic pathways is essential. This program is designed to provide a highly detailed, scientific overview of RAAS involvement in atherosclerosis. Understanding the mechanistic role of RAAS in inflammation and cardiometabolic physiology will help guide physicians, researchers, and healthcare professionals to prescribe appropriate agents with confidence in patients who present with complicated hypertension.
Learning Objectives:	• Provide greater understanding of the biochemical pathways of RAAS activation at the cellular level • Understand how angiotensin II can lead to the development of atherosclerosis • Differentiate mechanisms of action between ACE inhibitors and angiotensin receptor antagonists and apply this information to optimal patient selection and cardiovascular care
Faculty Disclosure:	The University of Florida College of Medicine has a conflict of interest policy that requires course faculty to disclose any real or apparent commercial financial affiliations related to the content of their presentations/materials. It is not assumed that these financial interests or affiliations will have an adverse impact on faculty presentations; they simply are noted here to fully inform participants. Dr. Quyyumi has indicated that he has a financial arrangement or affiliation with Berlex Laboratories Inc, Eli Lilly and Company, National Institutes of Health, Pfizer Inc, CV Therapeutics, Inc, Wyeth Pharmaceuticals, and Solvay Pharmaceuticals Inc. The types of affiliations/financial interests are grant/research support and honoraria.
Continuing Medical Education Credit:
	Accreditation
	The University of Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
	Credit
	The University of Florida College of Medicine designates this educational activity for a maximum of 1.5 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
	This continuing education activity was planned in accordance with the ACCME essentials and reviewed by Carl J. Pepine, MD, Program Chair.
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Commercial Support:	This CME activity is supported by an educational grant from Boehringer Ingelheim.
System Requirements:	In order to view the presentation, your computer must have a media player such as Windows Media Player, Quicktime, or RealOne.
CME Contact:	For any question regarding this Internet CME activity, please contact the Office of Continuing Medical Education at 352-265-8081.
	The University of Florida College of Medicine has received permission to use this copyrighted material within a CME activity on the internet.

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